Co-delivery of micronized urinary bladder matrix damps regenerative capacity of minced muscle grafts in the treatment of volumetric muscle loss injuries.
Minced muscle grafts (MG) promote de novo muscle fiber regeneration and neuromuscular strength recovery in small and large animal models of volumetric muscle loss.The most noteworthy limitation of this approach is its reliance on a finite supply of donor tissue.To address this shortcoming, this study sought to evaluate micronized acellular urinary